Microdosing lysergic acid diethylamide (LSD) involves taking a very small dose of the substance. Advocates of LSD microdosing claim the practice has numerous health benefits, such as improving cognition and mood and reducing pain. However, there is currently not enough scientific evidence to prove these claims are true.

Generally, the practice also means taking this amount at regular or semiregular intervals. While it may offer some benefits for mental health conditions, studies examining microdosing LSD are limited.